Prenatal Exposure to Air Toxics and Malignant Germ Cell Tumors in Young Children.

ABSTRACT:

Objective

To assess prenatal air toxics exposure and risk for childhood germ cell tumors (GCTs) by histological subtype (yolk sac tumor and teratoma).

Methods

In this case-control study, GCT cases less than 6 years (n = 243) identified from California Cancer Registry records were matched by birth year to cancer-free population controls (n = 147,100), 1984 to 2013. Routinely monitored air toxic exposures were linked to subjects' birth address. Logistic regression estimated GCT risks per interquartile range increase in exposure.

Results

Prenatal exposure to various highly-correlated, traffic-related air toxics during the second trimester increased GCT risk, particularly 1,3-butadiene (odds ratio [OR] = 1.51; 95% confidence interval [CI] = 1.01, 2.26) and meta/para-xylen

SUBMITTER: Hall C 

PROVIDER: S-EPMC6551274 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature