Ontology highlight
ABSTRACT:
SUBMITTER: Kim JM
PROVIDER: S-EPMC6551516 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20181108 6418
In bacteria, nascent proteins bear the pretranslationally generated N-terminal (Nt) formyl-methionine (fMet) residue. Nt-fMet of bacterial proteins is a degradation signal, termed fMet/N-degron. By contrast, proteins synthesized by cytosolic ribosomes of eukaryotes were presumed to bear unformylated Nt-Met. Here we found that the yeast formyltransferase Fmt1, although imported into mitochondria, could also produce Nt-formylated proteins in the cytosol. Nt-formylated proteins were strongly up-reg ...[more]