Ontology highlight
ABSTRACT:
SUBMITTER: Ix JH
PROVIDER: S-EPMC6551774 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Ix Joachim H JH Isakova Tamara T Larive Brett B Raphael Kalani L KL Raj Dominic S DS Cheung Alfred K AK Sprague Stuart M SM Fried Linda F LF Gassman Jennifer J JJ Middleton John P JP Flessner Michael F MF Block Geoffrey A GA Wolf Myles M
Journal of the American Society of Nephrology : JASN 20190513 6
<h4>Background</h4>Higher serum phosphate and fibroblast growth factor-23 (FGF23) levels may be modifiable to prevent cardiovascular disease in CKD. Short-term studies have reported modest efficacy in phosphate and FGF23 reduction with intestinal phosphate binders in CKD.<h4>Methods</h4>To investigate effects of lanthanum carbonate (LC; a phosphate binder) and/or nicotinamide (NAM; an inhibitor of active intestinal phosphate transport) on serum phosphate and FGF23 in stage 3b/4 CKD, we conducted ...[more]