Ontology highlight
ABSTRACT:
SUBMITTER: Kawai Y
PROVIDER: S-EPMC6553702 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Kawai Yasuhiro Y Nakayama Eri E Takahashi Kenta K Taniguchi Satoshi S Shibasaki Ken-Ichi KI Kato Fumihiro F Maeki Takahiro T Suzuki Tadaki T Tajima Shigeru S Saijo Masayuki M Lim Chang-Kweng CK
PLoS neglected tropical diseases 20190606 6
We investigated the growth properties and virulence in mice of three Zika virus (ZIKV) strains of Asian/American lineage, PRVABC59, ZIKV/Hu/Chiba/S36/2016 (ChibaS36), and ZIKV/Hu/NIID123/2016 (NIID123), belonging to the three distinct subtypes of this lineage. The American-subtype strain, PRVABC59, showed the highest growth potential in vitro, whereas the Southeast Asian-subtype strain, NIID123, showed the lowest proliferative capacity. Moreover, PRVABC59- and NIID123-infected mice showed the hi ...[more]