Dataset Information

Predicting Pancreatic Cancer Resectability and Outcomes Based on an Objective Quantitative Scoring System.

ABSTRACT:

Objective

To quantitatively assess the probability of tumor resection based on measurements of tumor contact with the major peripancreatic vessels.

Methods

This is a retrospective cohort study of pancreatic cancer patients treated between January 2001 and December 2015 in a single academic comprehensive cancer center. Radiographic measurements of the circumferential degree and length of solid tumor contact with major peripancreatic vessels were obtained from diagnostic pancreatic protocol computed tomography images and tested for correlation with tumor resection and margin status.

Results

Of 294 patients analyzed, 113 (38%) were resected, with 71 (63%) with negative margins. Based on the individual measurements of vascular involvement, a resectability scoring system (RSS) was created. The RSS correlated strongly with resection (P < 0.0001) and R0 resection (P < 0.0001) probabilities. Moreover, the RSS correlated with overall survival (P < 0.0001) and metastasis-free survival (P < 0.0001), being able to substratify resectable (P = 0.022) and unresectable patients (P = 0.014) into subgroups with different prognosis based on RSS scores.

Conclusions

Based on a comprehensive and systematic quantitative approach, we developed a scoring system that demonstrated excellent accuracy to predict tumor resection, surgical margin status, and prognosis.

SUBMITTER: Toesca DAS

PROVIDER: S-EPMC6553971 | biostudies-literature | 2019 May/Jun

REPOSITORIES: biostudies-literature

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Publications

Predicting Pancreatic Cancer Resectability and Outcomes Based on an Objective Quantitative Scoring System.

Toesca Diego A S DAS Jeffrey R Brooke RB von Eyben Rie R Pollom Erqi L EL Poullos Peter D PD Poultsides George A GA Fisher George A GA Visser Brendan C BC Koong Albert C AC Chang Daniel T DT

Pancreas 20190501 5

<h4>Objective</h4>To quantitatively assess the probability of tumor resection based on measurements of tumor contact with the major peripancreatic vessels.<h4>Methods</h4>This is a retrospective cohort study of pancreatic cancer patients treated between January 2001 and December 2015 in a single academic comprehensive cancer center. Radiographic measurements of the circumferential degree and length of solid tumor contact with major peripancreatic vessels were obtained from diagnostic pancreatic ...[more]

PMID: 31091207

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Project description:BackgroundSeveral scoring systems are used to assess fecal incontinence (FI), among which, the most commonly used are Wexner and Vaizey's scoring systems. However, there are significant lacunae in these scoring systems, due to which they are neither accurate nor comprehensive.AimTo develop a new scoring system for FI that is accurate, comprehensive, and easy to use.MethodsA pro forma was made in which six types of FI were included: solid, liquid, flatus, mucous, stress, and urge. The weight for each FI was determined by asking a group of patients and laypersons to give a disability score to each type of FI from 0 to 100 (0- least, 100- maximum disability). The disability was assessed on a modified EQ-5D+ (EuroQol) description system, 4D3L (4 dimensions and 3 levels) for each FI. The average score of each FI was calculated, divided by 10, and rounded off to determine the weight of each FI type. The scores for the three levels of frequency of each FI were assigned as never = 0 (No episode of FI ever), occasional = 1 (≤ 1 episode of FI/ wk), and common = 2 (> 1 episode of FI/ wk), and was termed as frequency score. The score for each FI would be derived by multiplying the frequency score and the weight for that FI type. In the second phase of the study, a group of colorectal surgeons was asked to rank the six FI types in order of severity, and their ranking was compared with the patient and laypersons' rankings.ResultsFifty patients and 50 laypersons participated in the study. The weight was assigned to each FI (solid-8, liquid-8, urge-7, flatus-6, mucus-6, and stress-5), and an new scoring system was formulated. The maximum possible score was 80 (total incontinence), and the least 0 (no incontinence). The surgeons' ranking of FI severity did not correlate well with patients' and laypersons' rankings of FI, highlighting that surgeons and patients may perceive the severity of FI differently.ConclusionA new scoring system for FI was formulated, which was simple, logical, comprehensive, and easy to use, and eliminated previous shortcomings. Patients' and surgeons' perceptions of FI severity of FI did not correlate well.

Dataset Information

Predicting Pancreatic Cancer Resectability and Outcomes Based on an Objective Quantitative Scoring System.

Objective

Methods

Results

Conclusions

Publications

Predicting Pancreatic Cancer Resectability and Outcomes Based on an Objective Quantitative Scoring System.

Similar Datasets

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