Decoding type I and III interferon signalling during viral infection.
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ABSTRACT:
SUBMITTER: Mesev EV
PROVIDER: S-EPMC6554024 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Decoding type I and III interferon signalling during viral infection.
Mesev Emily V EV LeDesma Robert A RA Ploss Alexander A
Nature microbiology 20190401 6
Interferon (IFN)-mediated antiviral responses are central to host defence against viral infection. Despite the existence of at least 20 IFNs, there are only three known cell surface receptors. IFN signalling and viral evasion mechanisms form an immensely complex network that differs across species. In this Review, we begin by highlighting some of the advances that have been made towards understanding the complexity of differential IFN signalling inputs and outputs that contribute to antiviral de ...[more]
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