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Two rare cases of pancreatic adenosquamous carcinoma: A review of the literature with focus on radiologic findings.

ABSTRACT: Pancreatic adenosquamous carcinoma (PASC) is a rare, aggressive subtype of pancreatic tumor with a poor prognostic outlook compared to the much more common pancreatic adenocarcinoma. Here we present two cases of the rare PASC and analyze the radiologic findings on computed tomography (CT) and 18F- fluorodeoxyglucose positron emission tomography (FDG-PET). Both cases involve 62-year-old women presenting with abdominal pain, nausea, and vomiting who on imaging were found to have infiltrating lobular pancreatic masses with ring enhancement on CT and peripheral hypermetabolism with central necrosis on FDG-PET. Location in the pancreas and involvement of adjacent structures differed in the two cases, resulting in varying progressive clinical manifestations. PASC is a rare subtype of pancreatic cancer with nonspecific imaging findings. Here we presented two cases of PASC supporting previously reported imaging findings suggestive of PASC with additional FDG-PET manifestations and SUV levels, which only few reports have previously described.

SUBMITTER: Cedeno Kelly K

PROVIDER: S-EPMC6554233 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Two rare cases of pancreatic adenosquamous carcinoma: A review of the literature with focus on radiologic findings.

Cedeno Kelly Karen K Moore Craig C

Radiology case reports 20190416 7

Pancreatic adenosquamous carcinoma (PASC) is a rare, aggressive subtype of pancreatic tumor with a poor prognostic outlook compared to the much more common pancreatic adenocarcinoma. Here we present two cases of the rare PASC and analyze the radiologic findings on computed tomography (CT) and 18F- fluorodeoxyglucose positron emission tomography (FDG-PET). Both cases involve 62-year-old women presenting with abdominal pain, nausea, and vomiting who on imaging were found to have infiltrating lobul ...[more]

PMID: 31194122

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Project description:BackgroundPrimary hepatic neuroendocrine carcinoma (PHNEC) is extremely rare. The diagnosis of PHNEC remains challenging-partly due to its rarity, and partly due to its lack of unique clinical features. Available treatment options for PHNEC include surgical resection of the liver tumor(s), radiotherapy, liver transplant, transcatheter arterial chemoembolization (TACE), and administration of somatostatin analogues.Case presentationWe report two male PHNEC cases and discuss the diagnosis and treatment options. Both cases presented with abdominal pain; case two also presented with symptoms of jaundice. The initial diagnosis for both cases was poorly differentiated grade 3 small-cell neuroendocrine carcinoma, based on imaging characteristics and the pathology of liver biopsies. Final diagnoses of PHNEC were arrived at by ruling out non-hepatic origins. Case one presented with a large tumor in the right liver lobe, and the patient was treated with TACE. Case two presented with tumors in both liver lobes, invasions into the left branch of hepatic portal vein, and metastasis in the hepatic hilar lymph node. This patient was ineligible for TACE and was allergic to the somatostatin analogue octreotide. This limited treatment options to supportive therapies such as albumin supplementation for liver protection. Patient one and two died at 61 and 109 days, respectively, following initial hospital admission.ConclusionsWe diagnosed both cases with poorly differentiated grade 3 small-cell PHNEC through imaging characteristics, immunohistochemical staining of liver biopsies, and examinations to eliminate non-hepatic origins. Neither TACE nor liver protection appeared to significantly extend survival time of the two patients, suggesting these treatments may be inadequate to improve survival of patients with poorly differentiated grade 3 small-cell PHNEC. The prognosis of poorly differentiated grade 3 small-cell PHNEC is poor due to limited and ineffective treatment options.

Dataset Information

Two rare cases of pancreatic adenosquamous carcinoma: A review of the literature with focus on radiologic findings.

Publications

Two rare cases of pancreatic adenosquamous carcinoma: A review of the literature with focus on radiologic findings.

Similar Datasets

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