Systematic Review of Polygenic Gene-Environment Interaction in Tobacco, Alcohol, and Cannabis Use.
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ABSTRACT:
SUBMITTER: Pasman JA
PROVIDER: S-EPMC6554261 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
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Systematic Review of Polygenic Gene-Environment Interaction in Tobacco, Alcohol, and Cannabis Use.
Pasman Joëlle A JA Verweij Karin J H KJH Vink Jacqueline M JM
Behavior genetics 20190520 4
Studies testing the effect of single genetic variants on substance use have had modest success. This paper reviewed 39 studies using polygenic measures to test interaction with any type of environmental exposure (G×E) in alcohol, tobacco, and cannabis use. Studies using haplotype combinations, sum scores of candidate-gene risk alleles, and polygenic scores (PS) were included. Overall study quality was moderate, with lower ratings for the polygenic methods in the haplotype and candidate-gene scor ...[more]
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