Ontology highlight
ABSTRACT:
SUBMITTER: Francardo V
PROVIDER: S-EPMC6554374 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Francardo Veronica V Geva Michal M Bez Francesco F Denis Quentin Q Steiner Lilach L Hayden Michael R MR Cenci M Angela MA
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20190401 2
Pridopidine is a small molecule in clinical development for the treatment of Huntington's disease. It was recently found to have high binding affinity to the sigma-1 receptor, a chaperone protein involved in cellular defense mechanisms and neuroplasticity. Here, we have evaluated the neuroprotective and neurorestorative effects of pridopidine in a unilateral 6-hydroxydopamine (6-OHDA) lesion model of parkinsonism in mice. By 5 weeks of daily administration, a low dose of pridopidine (0.3 mg/kg) ...[more]