Assessing for interaction between APOE ε4, sex, and lifestyle on cognitive abilities.

ABSTRACT:

Objective

To test for interactions between APOE ε4 genotype and lifestyle factors on worse cognitive abilities in UK Biobank.

Methods

Using UK Biobank cohort data, we tested for interactions between APOE ε4 allele presence, lifestyle factors of alcohol intake, smoking, total physical activity and obesity, and sex, on cognitive tests of reasoning, information processing speed, and executive function (n range = 70,988-324,725 depending on the test). We statistically adjusted for potential confounders of age, sex, deprivation, cardiometabolic conditions, and educational attainment.

Results

There were significant associations between APOE ε4 and worse cognitive abilities, independent of potential confounders, and between lifestyle risk factors and wor

SUBMITTER: Lyall DM 

PROVIDER: S-EPMC6556094 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature