Ontology highlight
ABSTRACT:
SUBMITTER: Wold EA
PROVIDER: S-EPMC6556150 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20180828 1
G-protein-coupled receptors (GPCRs) have been tractable drug targets for decades with over one-third of currently marketed drugs targeting GPCRs. Of these, the class A GPCR superfamily is highly represented, and continued drug discovery for this family of receptors may provide novel therapeutics for a vast range of diseases. GPCR allosteric modulation is an innovative targeting approach that broadens the available small molecule toolbox and is proving to be a viable drug discovery strategy, as e ...[more]