Ontology highlight
ABSTRACT:
SUBMITTER: Pajed L
PROVIDER: S-EPMC6556574 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Pajed Laura L Wagner Carina C Taschler Ulrike U Schreiber Renate R Kolleritsch Stephanie S Fawzy Nermeen N Pototschnig Isabella I Schoiswohl Gabriele G Pusch Lisa-Maria LM Wieser Beatrix I BI Vesely Paul P Hoefler Gerald G Eichmann Thomas O TO Zimmermann Robert R Lass Achim A
The Journal of biological chemistry 20190425 23
Lysosomal acid lipase (LAL) hydrolyzes cholesteryl ester (CE) and retinyl ester (RE) and triglyceride (TG). Mice globally lacking LAL accumulate CE most prominently in the liver. The severity of the CE accumulation phenotype progresses with age and is accompanied by hepatomegaly and hepatic cholesterol crystal deposition. In contrast, hepatic TG accumulation is much less pronounced in these mice, and hepatic RE levels are even decreased. To dissect the functional role of LAL for neutral lipid es ...[more]