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Long noncoding RNA TUG1 promotes airway smooth muscle cells proliferation and migration via sponging miR-590-5p/FGF1 in asthma.

ABSTRACT: The proliferation and migration of airway smooth muscle cells (ASMCs) plays an important role in asthma. Recently, the function of long noncoding RNA (lncRNA) in the ASMCs has been realized. This study tries to investigate the role of lncRNA TUG1 for the ASMCs and focus on the deepgoing mechanism in the proliferation and migration. In the asthma rat model, TUG1 expression level was increased comparing with control. In the cellular assay with gain and loss of functions, lncRNA TUG1 promoted the ASMCs proliferation and migration, and reduces apoptosis. In the mechanical investigation, results unveiled that miR-590-5p acted as the target of TUG1, while FGF1 was targeted by miR-590-5p. Overall, this study reveals the vital regulation of TUG1/miR-590-5p/FGF1 axis for the proliferation and migration of ASMCs.

SUBMITTER: Lin J

PROVIDER: S-EPMC6556671 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Long noncoding RNA TUG1 promotes airway smooth muscle cells proliferation and migration via sponging miR-590-5p/FGF1 in asthma.

Lin Junling J Feng Xiaokai X Zhang Jun J Tong Zhaohui Z

American journal of translational research 20190515 5

The proliferation and migration of airway smooth muscle cells (ASMCs) plays an important role in asthma. Recently, the function of long noncoding RNA (lncRNA) in the ASMCs has been realized. This study tries to investigate the role of lncRNA TUG1 for the ASMCs and focus on the deepgoing mechanism in the proliferation and migration. In the asthma rat model, TUG1 expression level was increased comparing with control. In the cellular assay with gain and loss of functions, lncRNA TUG1 promoted the A ...[more]

PMID: 31217885

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