Early Glomerular Hyperfiltration and Long-Term Kidney Outcomes in Type 1 Diabetes: The DCCT/EDIC Experience.

ABSTRACT:

Background and objectives

Glomerular hyperfiltration has been considered to be a contributing factor to the development of diabetic kidney disease (DKD). To address this issue, we analyzed GFR follow-up data on participants with type 1 diabetes undergoing ¹²⁵I-iothalamate clearance on entry into the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications study.

Design, setting, participants, & measurements

This was a cohort study of DCCT participants with type 1 diabetes who underwent an ¹²⁵I-iothalamate clearance (iGFR) at DCCT baseline. Presence of hyperfiltration was defined as iGFR levels ≥140 ml/min per 1.73 m², with secondary thresholds of 130 or 150 ml/min per 1.73 m². Cox pro

SUBMITTER: Molitch ME 

PROVIDER: S-EPMC6556717 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature