Dataset Information

Moderate- to high-intensity exercise does not modify cortical ?-amyloid in Alzheimer's disease.

ABSTRACT: Introduction:Animal models of Alzheimer's disease show that exercise may modify ?-amyloid (A?) deposition. We examined the effect of a 16-week exercise intervention on cortical A? in patients with mild-to-moderate Alzheimer's disease. Methods:Thirty-six patients with Alzheimer's disease were randomized to either one hour of aerobic exercise three times weekly for 16 weeks or usual care. Pre and post intervention, 11Carbon-Pittsburgh compound B positron emission tomography was carried out to assess cortical A?, and quantified using standardized uptake value rations (SUVRs). Results:The intervention showed no effect on follow-up SUVRs in a covariance analysis with group allocation, baseline intervention SUVR, age, sex, and baseline Mini-Mental State Examination as predictors. Change in SUVRs did not correlate with changes in measures of physical or aerobic fitness. Discussion:The present findings do not support an effect of exercise on A?. However, the relatively short intervention period may account for a lack of efficacy. Further studies should test earlier and longer interventions.

SUBMITTER: Frederiksen KS

PROVIDER: S-EPMC6556817 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease.

Frederiksen Kristian S KS Madsen Karine K Andersen Birgitte B BB Beyer Nina N Garde Ellen E Høgh Peter P Waldemar Gunhild G Hasselbalch Steen G SG Law Ian I

Alzheimer's & dementia (New York, N. Y.) 20190607

<h4>Introduction</h4>Animal models of Alzheimer's disease show that exercise may modify β-amyloid (Aβ) deposition. We examined the effect of a 16-week exercise intervention on cortical Aβ in patients with mild-to-moderate Alzheimer's disease.<h4>Methods</h4>Thirty-six patients with Alzheimer's disease were randomized to either one hour of aerobic exercise three times weekly for 16 weeks or usual care. Pre and post intervention, 11Carbon-Pittsburgh compound B positron emission tomography was carr ...[more]

PMID: 31198839

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Project description:Background: Exercise leads to a robust inflammatory response mainly characterized by the mobilization of leukocytes and an increase in circulating inflammatory mediators produced by immune cells and directly from the active muscle tissue. Both positive and negative effects on immune function and susceptibility to minor illness have been observed following different training protocols. While engaging in moderate activity may enhance immune function above sedentary levels, excessive amounts of prolonged, high-intensity exercise may impair immune function. Thus, the aim of the present review was to clarify the inflammatory effects in response to different exercise intensities. Methods: Search was performed on PubMed and was completed on July 31st, 2017. The studies were eligible if they met the predefined inclusion criteria: a) observational or interventional studies, b) conducted in healthy adults (18-65 years), c) written in Portuguese, English or Spanish, d) including moderate and/or intense exercise. Eighteen articles were included. The specific components that were examined included circulating blood levels of cytokines, leukocytes, creatine kinase (CK) and C-reactive protein (CRP). The methodological quality of the included studies was assessed. Results: Most of the intervention studies showed changes in the assessed biomarkers, although these changes were not consistent. White blood cells (WBC) had an increase immediately after intensive exercise (> 64% VO2max), without alteration after moderate exercise (46-64% VO2max). The results suggested an elevation of the pro-inflammatory cytokines, namely IL-6, followed by an elevation of IL-10 that were more evident after intense exercise bouts. CRP increased both after intense and moderate exercise, with peak increases up to 28 h. CK increased only after intensive and long exercising. Conclusion: In summary, intense long exercise can lead, in general, to higher levels of inflammatory mediators, and thus might increase the risk of injury and chronic inflammation. In contrast, moderate exercise or vigorous exercise with appropriate resting periods can achieve maximum benefit.

Dataset Information

Moderate- to high-intensity exercise does not modify cortical ?-amyloid in Alzheimer's disease.

Publications

Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease.

Similar Datasets

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