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Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression.

ABSTRACT: Sodium butyrate is a histone deacetylase inhibitor that affects various types of brain damages. To investigate the effects of sodium butyrate on hippocampal dysfunction that occurs after whole-brain irradiation in animal models and the effect of sodium butyrate on radiation exposure-induced cognitive impairments, adult C57BL/6 mice were intraperitoneally treated with 0.6 g/kg sodium butyrate before exposure to 10 Gy cranial irradiation. Cognitive impairment in adult C57BL/6 mice was evaluated via an object recognition test 30 days after irradiation. We also detected the expression levels of neurogenic cell markers (doublecortin) and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor. Radiation-exposed mice had decreased cognitive function and hippocampal doublecortin and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression. Sodium butyrate pretreatment reversed these changes. These findings suggest that sodium butyrate can improve radiation-induced cognitive dysfunction through inhibiting the decrease in hippocampal phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression. The study procedures were approved by the Institutional Animal Care and Use Committee of Korea Institute of Radiological Medical Sciences (approval No. KIRAMS16-0002) on December 30, 2016.

SUBMITTER: Lee HJ

PROVIDER: S-EPMC6557090 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression.

Lee Hae June HJ Son Yeonghoon Y Lee Minyoung M Moon Changjong C Kim Sung Ho SH Shin In Sik IS Yang Miyoung M Bae Sangwoo S Kim Joong Sun JS

Neural regeneration research 20190901 9

Sodium butyrate is a histone deacetylase inhibitor that affects various types of brain damages. To investigate the effects of sodium butyrate on hippocampal dysfunction that occurs after whole-brain irradiation in animal models and the effect of sodium butyrate on radiation exposure-induced cognitive impairments, adult C57BL/6 mice were intraperitoneally treated with 0.6 g/kg sodium butyrate before exposure to 10 Gy cranial irradiation. Cognitive impairment in adult C57BL/6 mice was evaluated vi ...[more]

PMID: 31089051

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Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression.

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Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression.

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