Ontology highlight
ABSTRACT:
SUBMITTER: Hanibuchi M
PROVIDER: S-EPMC6557207 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Hanibuchi Masaki M Kanoh Akira A Kuramoto Takuya T Saito Tatsuro T Tobiume Makoto M Saijo Atsuro A Kozai Hiroyuki H Kondo Mayo M Morizumi Shun S Yoneda Hiroto H Kagawa Kozo K Ogino Hirokazu H Sato Seidai S Kawano Hiroshi H Otsuka Kenji K Toyoda Yuko Y Nokihara Hiroshi H Goto Hisatsugu H Nishioka Yasuhiko Y
Oncotarget 20190604 38
The feasibility and required sensitivity of circulating free DNA (cfDNA)-based detection methods in second-line epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment are not well elucidated. We examined T790M and other activating mutations of <i>EGFR</i> by cfDNA to assess the clinical usability. In 45 non-small cell lung cancer (NSCLC) patients harboring activating <i>EGFR</i> mutations, cfDNAs were prepared from the plasma samples. <i>EGFR</i> mutations in cfDNA were ...[more]