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The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses.

ABSTRACT: Here we describe the complete genome of a new ebolavirus, Bombali virus (BOMV) detected in free-tailed bats in Sierra Leone (little free-tailed (Chaerephon pumilus) and Angolan free-tailed (Mops condylurus)). The bats were found roosting inside houses, indicating the potential for human transmission. We show that the viral glycoprotein can mediate entry into human cells. However, further studies are required to investigate whether exposure has actually occurred or if BOMV is pathogenic in humans.

SUBMITTER: Goldstein T

PROVIDER: S-EPMC6557442 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses.

Goldstein Tracey T Anthony Simon J SJ Gbakima Aiah A Bird Brian H BH Bangura James J Tremeau-Bravard Alexandre A Belaganahalli Manjunatha N MN Wells Heather L HL Dhanota Jasjeet K JK Liang Eliza E Grodus Michael M Jangra Rohit K RK DeJesus Veronica A VA Lasso Gorka G Smith Brett R BR Jambai Amara A Kamara Brima O BO Kamara Sorie S Bangura William W Monagin Corina C Shapira Sagi S Johnson Christine K CK Saylors Karen K Rubin Edward M EM Chandran Kartik K Lipkin W Ian WI Mazet Jonna A K JAK

Nature microbiology 20180827 10

Here we describe the complete genome of a new ebolavirus, Bombali virus (BOMV) detected in free-tailed bats in Sierra Leone (little free-tailed (Chaerephon pumilus) and Angolan free-tailed (Mops condylurus)). The bats were found roosting inside houses, indicating the potential for human transmission. We show that the viral glycoprotein can mediate entry into human cells. However, further studies are required to investigate whether exposure has actually occurred or if BOMV is pathogenic in humans ...[more]

PMID: 30150734

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