Nongenetic optical neuromodulation with silicon-based materials.

ABSTRACT: Optically controlled nongenetic neuromodulation represents a promising approach for the fundamental study of neural circuits and the clinical treatment of neurological disorders. Among the existing material candidates that can transduce light energy into biologically relevant cues, silicon (Si) is particularly advantageous due to its highly tunable electrical and optical properties, ease of fabrication into multiple forms, ability to absorb a broad spectrum of light, and biocompatibility. This protocol describes a rational design principle for Si-based structures, general procedures for material synthesis and device fabrication, a universal method for evaluating material photoresponses, detailed illustrations of all instrumentation used, and demonstrations of optically controlled nongeneti

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC6557640 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature