Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk.
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ABSTRACT:
SUBMITTER: Gagliano Taliun SA
PROVIDER: S-EPMC6558085 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk.
Alzheimer's & dementia (Amsterdam, Netherlands) 20190606
<h4>Introduction</h4>There is observational evidence that low circulating levels of vitamin B12 are associated with an increased risk of Alzheimer's disease.<h4>Methods</h4>We used a two-sample summary-statistics-based Mendelian randomization design to assess the relationship of genetic factors contributing to vitamin B12 with late-onset Alzheimer's disease risk.<h4>Results</h4>Our results do not support a causal role of decreased vitamin B12 levels on Alzheimer's disease risk.<h4>Discussion</h4 ...[more]
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