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Feasibility of replacing homemade solutions by commercial products for qualitative fit testing of particulate respirators: a mixed effect logistic regression study.

ABSTRACT: Qualitative fit testing is mandatory for tight-fitting respirators to ensure that the wearer fitted properly before entering a contaminated workplace. The purpose of this study was to evaluate the homemade solutions as substitution of commercial products for qualitative fit testing of particulate respirators. Two homemade solutions of Bitrex™ and saccharin were made according to the Occupational Safety and Health Administration (OSHA) regulation 29 CFR 1910.134. Threshold Screening Tests (TSTs) of commercial solutions, as well as homemade ones, were conducted on 62 participants in a random order. A placebo was also tested to assure the participants could distinguish its flavorless from other taste of solutions. There were no statistically significant differences between the commercial and homemade solutions representing that participants detected the bitter taste of the Bitrex™ and sweet taste of the saccharin solutions (96.8% vs. 91.9% and 93.5% vs. 83.9%, respectively). Homemade solutions that were stable and haven't been contained microbial contaminations, could be substituted for commercial products in qualitative fit testing of filtering face-piece respirators (FFRs). Overall, this protocol presents a practical and cost-benefit technique to assess the fit testing of FFRs.

SUBMITTER: Fakherpour A

PROVIDER: S-EPMC6558090 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Feasibility of replacing homemade solutions by commercial products for qualitative fit testing of particulate respirators: a mixed effect logistic regression study.

Fakherpour Anahita A Jahangiri Mehdi M Yousefinejad Saeed S Seif Mozhgan M

MethodsX 20190601

Qualitative fit testing is mandatory for tight-fitting respirators to ensure that the wearer fitted properly before entering a contaminated workplace. The purpose of this study was to evaluate the homemade solutions as substitution of commercial products for qualitative fit testing of particulate respirators. Two homemade solutions of Bitrex™ and saccharin were made according to the Occupational Safety and Health Administration (OSHA) regulation 29 CFR 1910.134. Threshold Screening Tests (TSTs) ...[more]

PMID: 31205864

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Project description:Practical approaches to protect individuals from ambient particulate matter (PM) are urgently needed in developing countries. Evidence on the health benefits of wearing particulate-filtering respirators is limited.We evaluated the short-term cardiovascular health effects of wearing respirators in China.A randomized crossover trial was performed in 24 healthy young adults in Shanghai, China in 2014. The subjects were randomized into two groups and wore particulate-filtering respirators for 48 hr alternating with a 3-week washout interval. Heart rate variability (HRV) and ambulatory blood pressure (BP) were continuously monitored during the 2nd 24 hr in each intervention. Circulating biomarkers were measured at the end of each intervention. Linear mixed-effect models were applied to evaluate the effects of wearing respirators on health outcomes.During the intervention periods, the mean daily average concentration of PM with an aerodynamic diameter < 2.5 ?m (PM2.5) was 74.2 ?g/m3. Compared with the absence of respirators, wearing respirators was associated with a decrease of 2.7 mmHg [95% confidence interval (CI): 0.1, 5.2 mmHg] in systolic BP and increases of HRV parameters, including 12.5% (95% CI: 3.8%, 21.2%) in high frequency (HF) power, 10.9% (95% CI: 1.8%, 20.0%) in the root mean square of the successive differences, and 22.1% (95% CI: 3.6%, 40.7%) in the percentage of normal RR intervals with duration > 50 msec different from the previous normal RR interval (pNN50). The presence of respirators was also associated with a decrease of 7.8% (95% CI: 3.5%, 12.1%) in the ratio of low frequency (LF)/HF power.Short-term wearing of particulate-filtering respirators may produce cardiovascular benefits by improving autonomic nervous function and reducing BP. Citation: Shi J, Lin Z, Chen R, Wang C, Yang C, Cai J, Lin J, Xu X, Ross JA, Zhao Z, Kan H. 2017. Cardiovascular benefits of wearing particulate-filtering respirators: a randomized crossover trial. Environ Health Perspect 125:175-180;?http://dx.doi.org/10.1289/EHP73.

Dataset Information

Feasibility of replacing homemade solutions by commercial products for qualitative fit testing of particulate respirators: a mixed effect logistic regression study.

Publications

Feasibility of replacing homemade solutions by commercial products for qualitative fit testing of particulate respirators: a mixed effect logistic regression study.

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