Ontology highlight
ABSTRACT:
SUBMITTER: Illingworth JJ
PROVIDER: S-EPMC6558156 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Illingworth Joseph J JJ Alanine Daniel G DG Brown Rebecca R Marshall Jennifer M JM Bartlett Helen E HE Silk Sarah E SE Labbé Geneviève M GM Quinkert Doris D Cho Jee Sun JS Wendler Jason P JP Pattinson David J DJ Barfod Lea L Douglas Alexander D AD Shea Michael W MW Wright Katherine E KE de Cassan Simone C SC Higgins Matthew K MK Draper Simon J SJ
Frontiers in immunology 20190604
The malaria genome encodes over 5,000 proteins and many of these have also been proposed to be potential vaccine candidates, although few of these have been tested clinically. RH5 is one of the leading blood-stage <i>Plasmodium falciparum</i> malaria vaccine antigens and Phase I/II clinical trials of vaccines containing this antigen are currently underway. Its likely mechanism of action is to elicit antibodies that can neutralize merozoites by blocking their invasion of red blood cells (RBC). Ho ...[more]