Ontology highlight
ABSTRACT:
SUBMITTER: Mutzel V
PROVIDER: S-EPMC6558282 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Mutzel Verena V Okamoto Ikuhiro I Dunkel Ilona I Saitou Mitinori M Giorgetti Luca L Heard Edith E Schulz Edda G EG
Nature structural & molecular biology 20190408 5
Gene-regulatory networks control the establishment and maintenance of alternative gene-expression states during development. A particular challenge is the acquisition of opposing states by two copies of the same gene, as in the case of the long non-coding RNA Xist in mammals at the onset of random X-chromosome inactivation (XCI). The regulatory principles that lead to stable mono-allelic expression of Xist remain unknown. Here, we uncover the minimal regulatory network that can ensure female-spe ...[more]