Neuroprotective mechanism of low-dose sodium nitrite in oxygen-glucose deprivation model of cerebral ischemic stroke in PC12 cells.
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ABSTRACT:
SUBMITTER: Shakib N
PROVIDER: S-EPMC6558507 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
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Neuroprotective mechanism of low-dose sodium nitrite in oxygen-glucose deprivation model of cerebral ischemic stroke in PC12 cells.
Shakib Nader N Khadem Ansari Mohammad Hassan MH Karimi Pouran P Rasmi Yousef Y
EXCLI journal 20190408
The purpose of this study was to clarify the mechanisms of the protective effects of low-dose sodium nitrite (SN) on oxygen and glucose deprivation (OGD)-induced endoplasmic reticulum (ER) stress in PC12 cells. The PC12 cells were exposed to 4 h of OGD and treated with 100 μmol SN. The expression and activity of ER stress markers, including PKR-like endoplasmic reticulum kinase (PERK), transcription factor 6 (ATF6), CCAAT/enhancer binding protein homologous protein (CHOP), as well as caspase-12 ...[more]
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