Dataset Information

Adherence to antiretroviral treatment and associated factors among people living with HIV and AIDS in CHITWAN, Nepal.

ABSTRACT:

Background

Adherence to ART is the primary determinant of viral suppression and the risk of transmission, disease progression and death. Adherence of at least 95% is needed for optimal suppression. This study aimed at determining the adherence to Anti-Retroviral Therapy (ART) and its associated factors among People Living with HIV and AIDS in ART Center of Chitwan, Nepal.

Methods

A descriptive cross-sectional study was conducted among 231 clients aged 18?years to 49?years taking ART from Bharatpur Hospital of Chitwan and those who have been enrolled in ART for at least 6?months, were interviewed. Systematic Sampling technique was used. Semi-structured questionnaire was prepared by taking reference from the AIDS Clinical Trial group questionnaire (ACTG). Adherence was measured by patient self report. Data was entered Epi Data 3.1 and analyzed using Statistical Package for Social Sciences (SPSS) software where the P value of ResultsThe overall adherence in the last month was found to be 87.4%. Wrist watch and mobiles were seen as a facilitating factor for taking ART on time as clients taking ART used to set alarm to get informed of the medication time. Adherence was associated with female sex (AOR?=?10.550 CI: 1.854-60.046), family consisting only parents and their children (AOR?=?4.877, CI: 1.246-19.079), having no habit of taking alcohol (AOR?=?5.842 CI: 1.294-26.383), HIV duration of more than 3?years (AOR?=?10.055 CI: 2.383-42.430), picking up ART medications on their own (AOR?=?7.861, CI: 1.670-36.998) and not having side effects of ART (AOR?=?8.832, CI: 2.059-37.890).

Conclusion

Identifying and evaluating the problems faced by ARV drug users can foster the achievement of ART related goals and addressing ART related problems in a rational way. Effective and appropriate monitoring of non adherence behaviors can help patients increase adherence level fostering improvement in treatment outcome.

SUBMITTER: Neupane S

PROVIDER: S-EPMC6558692 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Publications

Adherence to antiretroviral treatment and associated factors among people living with HIV and AIDS in CHITWAN, Nepal.

Neupane Sujan S Dhungana Govinda Prasad GP Ghimire Harish Chandra HC

BMC public health 20190610 1

<h4>Background</h4>Adherence to ART is the primary determinant of viral suppression and the risk of transmission, disease progression and death. Adherence of at least 95% is needed for optimal suppression. This study aimed at determining the adherence to Anti-Retroviral Therapy (ART) and its associated factors among People Living with HIV and AIDS in ART Center of Chitwan, Nepal.<h4>Methods</h4>A descriptive cross-sectional study was conducted among 231 clients aged 18 years to 49 years taking A ...[more]

PMID: 31182074

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Project description:IntroductionFollowing global efforts to increase antiretroviral therapy (ART) access and coverage, Ethiopia has made significant achievement with a 6.3% annual decline in the HIV/AIDS incidence rate between 1990 and 2016. Such success depends not only on access to ART but also on attaining optimum treatment adherence. Emerging studies in Ethiopia has shown the increasing prevalence of poor adherence and lack of the desired viral suppression, but the extent and factors associated with non-adherence to ART are not well known, especially in the current study setup. In this study, we examined the magnitude and factors associated with treatment and non-adherence to ART among people living with HIV in Benishangul-Gumuz Regional State, northwest Ethiopia.MethodsAn institutional facility based cross-sectional descriptive study was carried out among adult people living with HIV/AIDS from mid-December 2016 to February 2017 with only 98.9% response rate. Sociodemographic factors (age, gender, marital status and residential area), economic factors (educational status, income, asset possession, employment status, dietary diversity, nutritional status and food security), and clinical characteristics (CD4 count, duration on ART and history of opportunistic infections) were explanatory variables. ART non-adherence was measured using a visual analogue scale (VAS). We used binary logistic regression and subsequent multivariate logistic regression analysis to determine the factors associated with ART non-adherence.ResultOverall, 39.7% of the participants were found non-adherent to ART. Strong association was found between non-adherence to ART and young age below 25 years (AOR: 4.30, 95% CI [1.39-3.35]; p = 0.011), urban residential area (AOR: 2.78, CI [1.23-7.09], p = 0.043), lack of employment (AOR: 1.75, 95% CI [1.05-2.91], p = 0.032), food insecurity (AOR: 2.67, 95% CI [7.59-8.97]; p < 0.0001), malnutrition (AOR: 1.55, 95% CI [1.94-2.56]; p = 0.027) and opportunistic infections (AOR: 1.81, 95% CI [1.11-2.97]; p = 0.018).ConclusionThe prevalence of non-adherence to ART in this study was high. Sociodemographic and economic factors such as young age of below 25 years, urban residential area, lack of employment, food insecurity, malnutrition and opportunistic infections were among the factors associated with non-adherence to ART.

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Dataset Information

Adherence to antiretroviral treatment and associated factors among people living with HIV and AIDS in CHITWAN, Nepal.

Background

Methods

Conclusion

Publications

Adherence to antiretroviral treatment and associated factors among people living with HIV and AIDS in CHITWAN, Nepal.

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