Long-term functional outcome after laryngeal cancer treatment.
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ABSTRACT: Background
The functional outcome after the treatment of laryngeal cancer is tightly related to the quality of life of affected patients. The aim of this study is to describe the long-term morbidity and functional outcomes associated with the different treatment modalities for laryngeal cancer.Methods
Retrospective chart review of 477 patients undergoing curatively intended treatment for laryngeal cancer at our tertiary referral center from 2001 to 2014: Details on patient and disease characteristics, diagnostics and treatment related functional outcomes were analyzed.Results
With a median follow-up of 51?months, the crude rate of functional larynx preservation was 74.6%. Radiotherapy +/- chemotherapy was the dominant treatment modality (n =?359-75.3%), whereas 24.7% (n =?118) underwent primary surgery, with 58.5% (69) receiving adjuvant treatment. The 5-year laryngectomy-free survival was 57% (95% CI, 48-66%) after surgery vs. 69% (95% CI, 64-75%) after chemoradiotherapy (p ConclusionsPreserving the laryngeal function after cancer treatment is challenging. Advanced tumor stages, primary surgery and recurrence are related to a poor functional outcome. Therefore, the criteria for initial decision-making needs to be further refined.
SUBMITTER: Anschuetz L
PROVIDER: S-EPMC6558792 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Long-term functional outcome after laryngeal cancer treatment.
Anschuetz Lukas L Shelan Mohamed M Dematté Marco M Schubert Adrian D AD Giger Roland R Elicin Olgun O
Radiation oncology (London, England) 20190611 1
<h4>Background</h4>The functional outcome after the treatment of laryngeal cancer is tightly related to the quality of life of affected patients. The aim of this study is to describe the long-term morbidity and functional outcomes associated with the different treatment modalities for laryngeal cancer.<h4>Methods</h4>Retrospective chart review of 477 patients undergoing curatively intended treatment for laryngeal cancer at our tertiary referral center from 2001 to 2014: Details on patient and di ...[more]
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