ABSTRACT: OBJECTIVE:Previous studies suggest that breastfeeding reduces epithelial ovarian cancer (EOC) risk. However, the effects of age, timing and episode details on the EOC-breastfeeding relationship have not been examined. The objective of this study was to examine the association between breastfeeding factors and epithelial ovarian cancer. METHODS:We examined breastfeeding factors among parous women in a population-based, case-control study conducted in Pennsylvania, Ohio, and New York from 2003 to 2008. We compared 689 incident EOC cases to 1572 community controls. Multivariable unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) associated with breastfeeding patterns adjusting for potential confounders. RESULTS:Compared to never breastfeeding, breastfeeding any offspring was associated with a 30% reduction in EOC risk (OR?=?0.70; 95%CI?=?0.58-0.85). That association lasted more than 30?years (OR?=?0.69, 95%CI?=?0.53-0.88). An average breastfeeding episode of 3?months was also associated with reduced risk (OR?=?0.73, 95%CI?=?0.58-0.80). A greater number of breastfeeding episodes was associated with greater risk reduction (OR?=?0.78, 95%CI?=?0.64-0.96 and OR?=?0.49, 95%CI?=?0.36-0.68 1-2 and 3+ episodes, respectively, compared to never breastfed, trend p?=?0.01). Longer breastfeeding duration was also associated with reduced risk (OR?=?0.75 and 0.62 for less than and greater than 1-year total duration, respectively, compared to never breastfed). An earlier age at first breastfeeding was further associated with increased protection (OR?=?0.50-0.80, for first episode at age <25, 25-29, and 30+, respectively, trend p?=?0.001). CONCLUSIONS:Breastfeeding for as few as 3?months is associated with reduced EOC risk. Although this association decreases over time, it persists for more than 30?years. Longer cumulative duration, increasing number of breastfeeding episodes, and earlier age at first breastfeeding episode are each associated with increased benefit.
