Onco-metabolism: defining the prognostic significance of obesity and diabetes in women with brain metastases from breast cancer.

ABSTRACT: PURPOSE:Metabolic dysregulation has been implicated as a molecular driver of breast cancer in preclinical studies, especially with respect to metastases. We hypothesized that abnormalities in patient metabolism, such as obesity and diabetes, may drive outcomes in breast cancer patients with brain metastases. METHODS:We retrospectively identified 84 consecutive patients with brain metastases from breast cancer treated with intracranial radiation therapy. Radiation was delivered as whole-brain radiation to a median dose of 3000 cGy or stereotactic radiosurgery to a median dose of 2100 cGy. Kaplan Meier curves were generated for overall survival (OS) data and Mantel-Cox regression was performed to detect differences in groups. RESULTS:At analysis, 81 survival events had occurred and the median OS for the entire cohort was 21.7 months. Despite similar modified graded prognostic assessments, resection rates, and receptor status, BMI???25 kg/m2 (n?=?45) was associated with decreased median OS (13.7 vs. 30.6 months; p?

SUBMITTER: McCall NS 

PROVIDER: S-EPMC6558990 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature