A Hallucinogenic Serotonin-2A Receptor Agonist Reduces Visual Response Gain and Alters Temporal Dynamics in Mouse V1.
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ABSTRACT:
SUBMITTER: Michaiel AM
PROVIDER: S-EPMC6559379 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
A Hallucinogenic Serotonin-2A Receptor Agonist Reduces Visual Response Gain and Alters Temporal Dynamics in Mouse V1.
Michaiel Angie M AM Parker Philip R L PRL Niell Cristopher M CM
Cell reports 20190301 13
Sensory perception arises from the integration of externally and internally driven representations of the world. Disrupted balance of these representations can lead to perceptual deficits and hallucinations. The serotonin-2A receptor (5-HT<sub>2A</sub>R) is associated with such perceptual alterations, both in its role in schizophrenia and in the action of hallucinogenic drugs. Despite this powerful influence on perception, relatively little is known about how serotonergic hallucinogens influence ...[more]
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