Ontology highlight
ABSTRACT:
SUBMITTER: Lovallo WR
PROVIDER: S-EPMC6559710 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Lovallo William R WR Acheson Ashley A Cohoon Andrew J AJ Sorocco Kristen H KH Vincent Andrea S AS Hodgkinson Colin A CA Goldman David D
PloS one 20190611 6
Early life adversity (ELA) negatively affects health behaviors in adulthood, but pathways from ELA exposure to behavioral outcomes are poorly understood. ELA in childhood and adolescence may translate into adult outcomes by way of modified glucocorticoid signaling. The cortisol cotransporter, FKBP5 has a G-to-A substitution (rs9296158) that hinders cortisol trafficking within target cells, and this impaired glucocorticoid signaling may shape the long-term response to ELA. We used performance on ...[more]