Ontology highlight
ABSTRACT:
SUBMITTER: Arunagiri A
PROVIDER: S-EPMC6559786 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Arunagiri Anoop A Haataja Leena L Pottekat Anita A Pamenan Fawnnie F Kim Soohyun S Zeltser Lori M LM Paton Adrienne W AW Paton James C JC Tsai Billy B Itkin-Ansari Pamela P Kaufman Randal J RJ Liu Ming M Arvan Peter P
eLife 20190611
Biosynthesis of insulin - critical to metabolic homeostasis - begins with folding of the proinsulin precursor, including formation of three evolutionarily conserved intramolecular disulfide bonds. Remarkably, normal pancreatic islets contain a subset of proinsulin molecules bearing at least one free cysteine thiol. In human (or rodent) islets with a perturbed endoplasmic reticulum folding environment, non-native proinsulin enters intermolecular disulfide-linked complexes. In genetically obese mi ...[more]