Ontology highlight
ABSTRACT:
SUBMITTER: Styr B
PROVIDER: S-EPMC6559804 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Styr Boaz B Gonen Nir N Zarhin Daniel D Ruggiero Antonella A Atsmon Refaela R Gazit Neta N Braun Gabriella G Frere Samuel S Vertkin Irena I Shapira Ilana I Harel Michal M Heim Leore R LR Katsenelson Maxim M Rechnitz Ohad O Fadila Saja S Derdikman Dori D Rubinstein Moran M Geiger Tamar T Ruppin Eytan E Slutsky Inna I
Neuron 20190429 5
Maintaining average activity within a set-point range constitutes a fundamental property of central neural circuits. However, whether and how activity set points are regulated remains unknown. Integrating genome-scale metabolic modeling and experimental study of neuronal homeostasis, we identified mitochondrial dihydroorotate dehydrogenase (DHODH) as a regulator of activity set points in hippocampal networks. The DHODH inhibitor teriflunomide stably suppressed mean firing rates via synaptic and ...[more]