Ontology highlight
ABSTRACT:
SUBMITTER: Pascual-Garcia M
PROVIDER: S-EPMC6559950 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Pascual-García Mónica M Bonfill-Teixidor Ester E Planas-Rigol Ester E Rubio-Perez Carlota C Iurlaro Raffaella R Arias Alexandra A Cuartas Isabel I Sala-Hojman Ada A Escudero Laura L Martínez-Ricarte Francisco F Huber-Ruano Isabel I Nuciforo Paolo P Pedrosa Leire L Marques Carolina C Braña Irene I Garralda Elena E Vieito María M Squatrito Massimo M Pineda Estela E Graus Francesc F Espejo Carmen C Sahuquillo Juan J Tabernero Josep J Seoane Joan J
Nature communications 20190611 1
Cancer response to immunotherapy depends on the infiltration of CD8<sup>+</sup> T cells and the presence of tumor-associated macrophages within tumors. Still, little is known about the determinants of these factors. We show that LIF assumes a crucial role in the regulation of CD8<sup>+</sup> T cell tumor infiltration, while promoting the presence of protumoral tumor-associated macrophages. We observe that the blockade of LIF in tumors expressing high levels of LIF decreases CD206, CD163 and CCL2 ...[more]