Evolutionary and functional implications of 3' untranslated region length of mRNAs by comprehensive investigation among four taxonomically diverse metazoan species.

ABSTRACT: BACKGROUND:In eukaryotic organisms, it has been well acknowledged that 3' untranslated regions (3' UTRs) of mRNA are actively involved in post-transcriptional regulations of gene expression. Although both shortening and lengthening of 3' UTRs of specific candidate genes were explicitly documented to have functional consequences, landscape of 3' UTR lengths in relation to evolutionary dynamics and biological meanings remains to be elucidated when large-scale data become available. OBJECTIVES:The primary objective of this study was to revealed different inter- and intra-species patterns on length distribution of 3' UTRs in comparison with 5' UTRs and coding regions. METHODS:In the present study, we investigated 3' UTR lengths in a highly curated set of 57,135 mRNA sequences among four well-s

SUBMITTER: Wang W 

PROVIDER: S-EPMC6560010 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature