Perinatal risk factors for type 1 diabetes revisited: a population-based register study.

ABSTRACT:

Aims/hypothesis

Single-centre studies and meta-analyses have found diverging results as to which early life factors affect the risk of type 1 diabetes during childhood. We wanted to use a large, nationwide, prospective database to further clarify and analyse the associations between perinatal factors and the subsequent risk for childhood-onset type 1 diabetes using a case-control design.

Methods

The Swedish Childhood Diabetes Register was linked to the Swedish Medical Birth Register and National Patient Register, and 14,949 cases with type 1 diabetes onset at ages 0-14 years were compared with 55,712 matched controls born from the start of the Medical Birth Register in 1973 to 2013. After excluding confounders (i.e. children multiple births, those whose mother had maternal d

SUBMITTER: Waernbaum I 

PROVIDER: S-EPMC6560018 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature