A catalog of single nucleotide changes distinguishing modern humans from archaic hominins.

ABSTRACT: Throughout the past decade, studying ancient genomes has provided unique insights into human prehistory, and differences between modern humans and other branches like Neanderthals can enrich our understanding of the molecular basis of unique modern human traits. Modern human variation and the interactions between different hominin lineages are now well studied, making it reasonable to go beyond fixed genetic changes and explore changes that are observed at high frequency in present-day humans. Here, we identify 571 genes with non-synonymous changes at high frequency. We suggest that molecular mechanisms in cell division and networks affecting cellular features of neurons were prominently modified by these changes. Complex phenotypes in brain growth trajectory and cognitive traits are likel

SUBMITTER: Kuhlwilm M 

PROVIDER: S-EPMC6560109 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature