Indoleamine 2,3-dioxygenase and ischemic heart disease: a Mendelian Randomization study.
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ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC6560130 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
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Indoleamine 2,3-dioxygenase and ischemic heart disease: a Mendelian Randomization study.
Li Mengyu M Kwok Man Ki MK Fong Shirley Siu Ming SSM Schooling Catherine Mary CM
Scientific reports 20190611 1
Tryptophan is an essential amino acid. Indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme in the tryptophan-kynurenine pathway, is positively associated with cardiac events, and may be relevant to cancer. We used Mendelian Randomization to obtain unconfounded estimates of the association of IDO1 with ischemic heart disease (IHD), ischemic stroke and their risk factors, all-cancer, cancer of the prostate, lung and bronchus, and breast. We obtained genetic instruments independently and st ...[more]
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