Long non-coding RNA FLJ33360 participates in ovarian cancer progression by sponging miR-30b-3p.

ABSTRACT:

Background

Long noncoding RNAs (lncRNAs) have been reported to play a key role in the development and progression of human malignancies. FLJ33360 is an lncRNA with unknown functions. This study was designed to determine the clinical significance and mechanism of FLJ33360 in ovarian cancer.

Materials and methods

The clinical significance of FLJ33360 in ovarian cancer was determined using the Gene Expression Profiling Interactive Analysis (GEPIA) database, Kaplan-Meier Plotter database, quantitative reverse transcription polymerase chain reaction (qRT-PCR) and statistical analysis. The regulatory relationships between FLJ33360 and miR-30b-3p were explored through bioinformatics, the Gene Expression Omnibus (GEO) database, the ArrayExpress database and meta-analysis. The possib

SUBMITTER: Yang M 

PROVIDER: S-EPMC6560195 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature