Anti-inflammatory activity of intravenous immunoglobulin through scavenging of heme.
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ABSTRACT:
SUBMITTER: Wiatr M
PROVIDER: S-EPMC6560225 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Anti-inflammatory activity of intravenous immunoglobulin through scavenging of heme.
Wiatr Marie M Merle Nicolas S NS Boudhabhay Idris I Poillerat Victoria V Rossini Sofia S Lecerf Maxime M Kaveri Srini V SV Lacroix-Desmazes Sébastian S Roumenina Lubka T LT Dimitrov Jordan D JD
Molecular immunology 20190510
Therapeutic intravenous immunoglobulin preparations (IVIg) are used for treatment of wide range of autoimmune and inflammatory diseases. Versatile mechanisms have been reported to contribute to the immunomodulatory effects of IVIg. Here we demonstrate that IVIg has a strong potential to inhibit pro-inflammatory effect of extracellular heme. Indeed, the presence of immunoglobulins reduced the potential of heme to activate the complement system on the surface of human endothelial cells. Since extr ...[more]
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