Vitamin D levels and influenza vaccine immunogenicity among HIV-infected and HIV-uninfected adults.

ABSTRACT:

Background

Vaccination is the most important preventive strategy against influenza, however post-vaccination antibody responses are often inadequate especially among HIV-infected persons. Vitamin D deficiency has been suggested to adversely influence immune responses and is highly prevalent among HIV-infected adults. Therefore, we evaluated the association between 25-hydroxyvitamin D [25(OH)D] levels and post-influenza vaccination responses.

Methods

We conducted a prospective cohort study evaluating the immunogenicity of monovalent influenza A (H1N1) vaccination among both HIV-infected and HIV-uninfected adults (18-50years of age) during the 2009-2010 influenza season. Antibody titers were evaluated at baseline, day 28, and 6months post-vaccination using hemagluttination inh

SUBMITTER: Crum-Cianflone NF 

PROVIDER: S-EPMC6560638 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature