Emergence of stable striatal D1R and D2R neuronal ensembles with distinct firing sequence during motor learning.

ABSTRACT: The dorsolateral striatum (DLS) is essential for motor and procedure learning, but the role of DLS spiny projection neurons (SPNs) of direct and indirect pathways, as marked, respectively, by D1 and D2 receptor (D1R and D2R) expression, remains to be clarified. Long-term two-photon calcium imaging of the same neuronal population during mouse learning of a cued lever-pushing task revealed a gradual emergence of distinct D1R and D2R neuronal ensembles that reproducibly fired in a sequential manner, with more D1R and D2R neurons fired during the lever-pushing period and intertrial intervals (ITIs), respectively. This sequential firing pattern was specifically associated with the learned motor behavior, because it changed markedly when the trained mice performed other cued motor tasks. Selecti

SUBMITTER: Sheng MJ 

PROVIDER: S-EPMC6561210 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature