Modelling the potential impact of providing preexposure prophylaxis in pregnant and breastfeeding women in South Africa.

ABSTRACT:

Objective

HIV-uninfected pregnant and breastfeeding women are at high risk of HIV acquisition, contributing to vertical transmission of HIV. Preexposure prophylaxis (PrEP) is safe in pregnancy, but PrEP in pregnancy is not policy in many countries including South Africa. We evaluated the potential impact of providing PrEP for pregnant/breastfeeding women using a HIV model for South Africa.

Methods

Our model considers two scenarios: a conservative scenario that matches the experience reported in the Kenyan PrEP programme for pregnant women (probability of uptake = 32% and 11% in high-risk and low-risk women, respectively); and an optimistic scenario with PrEP initiated by 80% of all pregnant women. We compared this with PrEP for female sex workers, MSM and adolescent girls/yo

SUBMITTER: Joseph Davey DL 

PROVIDER: S-EPMC6561341 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature