The benefit of immediate compared with deferred antiretroviral therapy on CD4+ cell count recovery in early HIV infection.

ABSTRACT:

Objective

To assess the impact of immediate vs. deferred antiretroviral therapy (ART) on CD4 recovery among individuals early in HIV infection.

Design

Using serologic markers of early infection together with self-reported dates of infection and HIV diagnosis, ART-naive participants who were randomized to immediate vs. deferred ART in the Strategic Timing of Antiretroviral Treatment trial were classified into subgroups of duration of HIV infection at baseline. CD4 cell count recovery over follow-up according to duration of HIV infection was investigated.

Methods

Three subgroups were defined: first, infected 6 months or less (n = 373); second, infected 6-24 months (n = 2634); and third, infected 24 months or longer (n = 1605). Follow-up CD4, CD8, and CD4 : CD8 ratio for

SUBMITTER: Sharma S 

PROVIDER: S-EPMC6561661 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature