The BD2 domain of BRD4 is a determinant in EndoMT and vein graft neointima formation.

ABSTRACT:

Background

Vein-graft bypass is commonly performed to overcome atherosclerosis but is limited by high failure rates, principally due to neointimal wall thickening. Recent studies reveal that endothelial-mesenchymal transition (EndoMT) is critical for vein-graft neointima formation. BETs are a family of Bromo/ExtraTerminal domains-containing epigenetic reader proteins (BRD2, BRD3, BRD4). They bind acetylated histones through their unique tandem bromodomains (BD1, BD2), facilitating transcriptional complex formation and cell-state transitions. The role for BETs, including individual BRDs and their unique BDs, is not well understood in EndoMT and neointimal formation.

Methods and results

Repression of BRD4 expression abrogated TGFβ1-induced EndoMT, with greater effects than BRD

SUBMITTER: Zhang M 

PROVIDER: S-EPMC6561802 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature