Plasminogen activator inhibitor-1 polymorphisms as a risk factor for chronic periodontitis in North Indian population.

ABSTRACT:

Objectives

Impaired plasminogen activator inhibitor-1 (PAI-1), controlling coagulation and the fibrinolytic system is supposed to be involved in the pathogenesis of periodontitis. This study was performed to examine the association of PAI-1 gene polymorphisms with Chronic Periodontitis (CP) and alveolar bone loss severity involved with the disease and for understanding the role of genetic contributions in disease progression.

Methods

87 volunteers were included in the study. Genomic DNA was isolated from peripheral blood, subsequently, DNA samples were subjected to polymerase chain reaction and endonuclease digestion. Direct gene sequencing were performed for all the samples to identify genotype polymorphisms (rs 11560324) in the 3' untranslated region of PAI-1 gene. For bon

SUBMITTER: Debnath P 

PROVIDER: S-EPMC6561901 | biostudies-literature | 2019 Apr-Jun

REPOSITORIES: biostudies-literature