Ontology highlight
ABSTRACT:
SUBMITTER: Brear P
PROVIDER: S-EPMC6562204 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20180509 11
Increased CK2 levels are prevalent in many cancers. Combined with the critical role CK2 plays in many cell-signaling pathways, this makes it a prime target for down regulation to fight tumour growth. Herein, we report a fragment-based approach to inhibiting the interaction between CK2α and CK2β at the α-β interface of the holoenzyme. A fragment, CAM187, with an IC<sub>50</sub> of 44 μM and a molecular weight of only 257 gmol<sup>-1</sup> has been identified as the most promising compound. Import ...[more]