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Complete response to perioperative treatment using nivolumab for metastatic renal cell carcinoma: A case report.


ABSTRACT: We report a case of 59-year-old woman who has multiple lung metastases with renal cell carcinoma (RCC). She received neoadjuvant therapy using nivolumab following sunitinib. Thereafter, we performed cytoreductive nephrectomy and subsequently administered nivolumab. We also found a high expression of PD-L1 in tumor cell and infiltration of lymphocytes with CD8 expression by immunohistochemistry. A complete response was achieved 4 months after surgery. A perioperative treatment using nivolumab might be useful treatment for metastatic RCC.

SUBMITTER: Ikarashi D 

PROVIDER: S-EPMC6562266 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Complete response to perioperative treatment using nivolumab for metastatic renal cell carcinoma: A case report.

Ikarashi Daiki D   Nakamura Yasuyuki Y   Shimodate Hitoshi H   Usui Yoshitaka Y   Ujiie Takashi T   Obara Wataru W  

Urology case reports 20190130


We report a case of 59-year-old woman who has multiple lung metastases with renal cell carcinoma (RCC). She received neoadjuvant therapy using nivolumab following sunitinib. Thereafter, we performed cytoreductive nephrectomy and subsequently administered nivolumab. We also found a high expression of PD-L1 in tumor cell and infiltration of lymphocytes with CD8 expression by immunohistochemistry. A complete response was achieved 4 months after surgery. A perioperative treatment using nivolumab mig  ...[more]

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