Ontology highlight
ABSTRACT:
SUBMITTER: Zahedi A
PROVIDER: S-EPMC6562374 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Zahedi Atena A Phandthong Rattapol R Chaili Angela A Leung Sara S Omaiye Esther E Talbot Prue P
iScience 20190528
Stem cells provide a sensitive model to study exposure to toxicants, such as cigarette smoke. Electronic cigarettes (ECs) are popular nicotine delivery devices, often targeted to youth and pregnant mothers. However, little is known about how chemicals in ECs might affect neural stem cells, and in particular their mitochondria, organelles that maintain cell functionality and health. Here we show that the mechanism underlying EC-induced stem cell toxicity is stress-induced mitochondrial hyperfusio ...[more]