Ontology highlight
ABSTRACT:
SUBMITTER: Hung MS
PROVIDER: S-EPMC6562482 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Hung Ming-Szu MS Chen Yi-Chuan YC Lin PaulYann P Li Ya-Chin YC Hsu Chia-Chen CC Lung Jr-Hau JH You Liang L Xu Zhidong Z Mao Jian-Hua JH Jablons David M DM Yang Cheng-Ta CT
Cancers 20190502 5
<b>:</b> Cullin 4A (Cul4A) is overexpressed in a number of cancers and has been established as an oncogene. This study aimed to elucidate the role of Cul4A in lung cancer invasion and metastasis. We observed that Cul4A was overexpressed in non-small cell lung cancer (NSCLC) tissues and the overexpression of Cul4A was associated with poor prognosis after surgical resection and it also decreased the expression of the tumor suppressor protein annexin A10 (ANXA10). The knockdown of Cul4A was associa ...[more]