Targeting ATG4 in Cancer Therapy.
Ontology highlight
ABSTRACT:
SUBMITTER: Fu Y
PROVIDER: S-EPMC6562779 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Targeting ATG4 in Cancer Therapy.
Fu Yuanyuan Y Huang Zhiying Z Hong Liang L Lu Jia-Hong JH Feng Du D Yin Xiao-Ming XM Li Min M
Cancers 20190510 5
Autophagy is a lysosome-mediated degradation pathway that enables the degradation and recycling of cytoplasmic components to sustain metabolic homoeostasis. Recently, autophagy has been reported to have an astonishing number of connections to cancer, as tumor cells require proficient autophagy in response to metabolic and therapeutic stresses to sustain cell proliferation. Autophagy-related gene 4 (ATG4) is essential for autophagy by affecting autophagosome formation through processing full-leng ...[more]
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